Molecular mechanism of spirit-quieting traditional Chinese medicine in the treatment of prostate cancer metastasis patients with depression

Abstract

Prostate cancer is a common male urinary system cancer globally with a poor prognosis. Our research aims to explore the role of spirit-quieting Traditional Chinese Medicine in the treatment of prostate cancer metastasis patients with depression and its underlying mechanism. Currently, based on the theory of enzyme-activated bone degradation, we consider that MAOA mediates a vicious cycle among tumor cells, osteoblasts, osteoclasts and stromal cells facilitating PCa metastasis to bone and visceral organs, which was effectively reduced by TCM MAOA inhibition disengaging the Shh-IL6-RANKL signaling network in the tumor microenvironment. Additionally, the protein expression level of MAOA was found by using clinical specimens from the HPA database.