Molecular mechanism of spirit-quieting traditional Chinese medicine in the treatment of prostate cancer metastasis patients with depression

宁神中药治疗前列腺癌转移伴抑郁症的分子机制：前列腺癌是全球常见的男性泌尿系统癌症，预后较差。本研究旨在探讨宁神中药治疗前列腺癌转移伴抑郁症的作用及其机制。目前，基于酶激活骨降解理论，我们认为 MAOA 介导肿瘤细胞、成骨细胞、破骨细胞和基质细胞之间的恶性循环，促进 PCa 向骨和内脏器官的转移，通过中药 MAOA 抑制释放肿瘤微环境中的 Shh-IL6-RANKL 信号网络。此外，通过使用来自 HPA 数据库的临床标本，发现了 MAOA 的蛋白质表达水平。

Abstract

Prostate cancer is a common male urinary system cancer globally with a poor prognosis. Our research aims to explore the role of spirit-quieting Traditional Chinese Medicine in the treatment of prostate cancer metastasis patients with depression and its underlying mechanism. Currently, based on the theory of enzyme-activated bone degradation, we consider that MAOA mediates a vicious cycle among tumor cells, osteoblasts, osteoclasts and stromal cells facilitating PCa metastasis to bone and visceral organs, which was effectively reduced by TCM MAOA inhibition disengaging the Shh-IL6-RANKL signaling network in the tumor microenvironment. Additionally, the protein expression level of MAOA was found by using clinical specimens from the HPA database.