Multidisciplinary Collaborative Predictive Care in the World’s First ALPPS Combined with Intraoperative Isolated Perfusion Chemotherapy for Diseased Liver Staged Hepatectomy

Abstract

To summarize the nursing experience of a three-stage liver resection combined with ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) and intraoperative isolated perfusion chemotherapy for a patient at a tertiary hospital in Shenzhen, China, in order to provide insights for the treatment of such cases in the future. This operation was conducted for the first time globally, presenting significant challenges and no prior nursing experience to reference. Through evidence-based thinking and literature review, preoperative multidisciplinary team (MDT) collaboration was implemented for the patient. This included psychological support, rehabilitation planning, preoperative exercise regimens, comprehensive nutritional interventions, standardized pain management, and close monitoring of the patient's blood drug concentrations during the operation. Intraoperatively, prevention and observation of potential complications were prioritized. As a result of the MDT interventions, the patient did not experience any related complications or adverse events during the perioperative period and was successfully discharged after recovery. Follow-up examinations conducted one month, six months, and one year post-discharge revealed no tumor recurrence, with all outcomes being favorable.