The role of SGOL1 in the prognosis of skin cutaneous melanoma (SKCM)

Abstract

Objective: To analyze the expression of SGOL1 in skin cutaneous melanoma(SKCM) and its relationship with prognosis. 
Methods: The expression of SGOL1 in SKCM and normal tissues was analyzed by TCGA database. Kaplan-Meier curve was used to analyze the relationship between SGOL1 expression and prognosis of SKCM. Mann-Whitney U test and Kruskal-Wallis test were used to analyze the relationship between SGOL1 and clinicopathological features. 
Results: SGOL1 was over expressed in SKCM (P <0.05). The overall survival of SGOL1 high expression group was lower than low expression group (P < 0.05). There was no difference in the expression of SGOL1 between gender or age groups, but there were different in the expression of SGOL1 between Clark grades, tumor stages and survival status. 
Conclusion: High expression of SGOL1 in SKCM may be related with poor prognosis.